Homeboy, homegirl, homes (plural and singular, male or female) and homies (plural and singular, male or female) are commonly used by Hispanics in the USA. It refers to someone from the same "barrio" or neighborhood. In a conversation, it is often used much like "cara" in Brazil except when it follows a possessive pronoun when it implies friendship.
Homes, see that homeboy on the corner? He pumps gas. (Hey, do you see that guy on the corner? He works at a gas station.)
I want you to meet Rabbit, my homie. (I want to introduce my friend Rabbit.)
Homegirl, where you going? (Hey, where are you going?)